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Cannabis and Traumatic Brain Injury

How can plant-based cannabinoids offer benefits for Traumatic Brain Injury? Read this summary of the research on cannabis and Traumatic Brain Injury.

Emerging research suggests that cannabinoids, particularly cannabidiol (CBD), may offer neuroprotective benefits in traumatic brain injury. CBD's mechanisms include reducing inflammation, mitigating oxidative stress, and enhancing blood-brain barrier integrity, all of which are crucial in the underlying physiology of TBI. Preclinical studies have demonstrated that CBD can decrease lesion volumes and improve cognitive and motor functions following moderate to severe TBI. 

Sources

Palazzo, Enza, et al. "Cannabidiol in traumatic brain injury." Diagnosis and Treatment of Traumatic Brain Injury. Academic Press, 2022. 463-475.; Dong, Shiying, et al. "Cannabidiol alleviates neurological deficits after traumatic brain injury by improving intracranial lymphatic drainage." Journal of neurotrauma 41.15-16 (2024: e2009-e2025.)

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